TGFβ/TGFβR3 Signaling Pathways in Autoimmune Disease

  • Reggie Holifield The University of Montevallo
  • Christine Sestero, Mentor The University of Montevallo


This research project focuses on the effect that the TGFβ/TGFβR3 immune cell signaling pathway has on antibody production in mice immunized with a T cell-independent antigen. Sera were collected from two groups of mice immunized with a trinitrophenyl (TNP) antigen: a transgenic group lacking the TGFβ/TGFβR3 signaling pathway and a littermate control group with an intact signaling pathway. Sera were collected 0-42 days following immunization. The indirect enzyme-linked immunosorbent assay (ELISA) was utilized to detect different subclasses of anti-TNP antibodies (IgM, IgG1, IgG2b, IgG2c, and IgG3). This project contributes to investigating whether variations in the TGFβ/TGFβR3 cell signaling pathway affect antibody production associated with certain types of autoimmune disease and the potential for therapies targeting this pathway as treatment for such diseases2.

May 8, 2017
How to Cite
HOLIFIELD, Reggie; SESTERO, MENTOR, Christine. TGFβ/TGFβR3 Signaling Pathways in Autoimmune Disease. Metamorphosis, [S.l.], may 2017. Available at: <>. Date accessed: 24 may 2017.
Natural Sciences